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In a phase III study, known as COSMIC-312 (NCT03755791), which compared cabozantinib in combination with atezolizumab to sorafenib as a first-line therapy for advanced HCC, the combination therapy significantly improved PFS [142]

PMID 16608839

& Inoue, M

The oocyte develops within the FF environment and this intimately affects the quality of oocytes and their interaction with sperm, thus affecting implantation and embryonic development [386] (Figure 2)