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Lastly, positional constraints were applied only to the protein backbone alpha carbons for a further 20 ns

[47]: Their study found that when intervening in post-SCI skeletal muscle atrophy by means of a PGC-1 activator, a significant difference in the level of PGC-1 expression appeared in skeletal muscle undergoing the intervention in the early stages of the injury, with no significant difference at the chronic stage

Based on the currently available literature, TNFi has, therefore, become the first choice of bDMARDs therapy in RA patients not responding to, or intolerant of, a conventional sDMARD treatment