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The activation of regions involved with the nicotine addiction pathway (that have high concentrations of nAChR receptors) causes nicotine-induced firing and activity of dopamine neurons in the brain 2

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The similarities between the cancer-causing chemicals in various Natural American Spirit cigarettes are consistent with the knowledge that harmful chemicals in cigarette smoke come from the tobacco plant itself or from the combustion process, and do not depend on tobacco being organic or natural, says Aleksandra Alcheva, a School of Public Health graduate student and study co-author

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