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A significant shift in smuggling would not only severely limit the positive revenue potential of the tax increase and the public health benefits but could also boost criminal activity in the state

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Huang, C

However, considering the relatively recent introduction of HTPs, in contrast to the long latency periods typically required for the development of smoking-related chronic diseases, as well as the evolving design and composition of these products, it is not surprising that definitive conclusions regarding their clinical, and public health impact bring up the need to be integrated by long-term evidence derived from independently conducted studies