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Everyone reacts to cannabis a little differently, but heres what you might expect from your first smoke session: A sense of relaxation or calm Heightened sensory perception (music, colors, food may feel more intense) A light, euphoric buzz or giggles Dry mouth or cottonmouth (have water nearby!) Slight coughing or throat irritationespecially if its your first time inhaling smoke For some, what does smoking weed feel like may also include drowsiness, light-headedness, or even mild anxiety