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In hypoxia, multiple systemic responses are induced, including angiogenesis, erythropoiesis and glycolysis [52, 53, 56, 7173]

A., Marques, J

Estrogen plays a critical role in collagen production, skin hydration, bone density, and hair follicle cycling

Melatonins decline in aging has widespread implications weakening circadian coordination, diminishing sleep quality, lowering antioxidant defense, increasing inflammation, and reducing neuroprotection, all of which may contribute to accelerated aging and age-related diseases