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In this context, it is widely accepted that platelet and leukocyte activation as well as endothelial dysfunction are associated with atherogenesis and cardiovascular morbidity [18, 19]

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In Italy, perhaps more than in many other places, smoking has interacted with the national culture - social, economic, political, and artistic - in profound and telling ways

Brand choice creates some variability, from around 12 for the cheapest budget lines to 18 or more for premium products, but the underlying tax structure means no brand offers genuinely affordable access to cigarettes for regular smokers