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Moreover, treatment with GP in mice with DSS-induced colitis resulted in the suppression of pro-inflammatory cytokines TNF-, IL-6, IL-1, IL-17A, and IFN-, modulation of intestinal barrier-related factors occludin-1 and ZO-1, enhancement of intestinal flora diversity, and an increase in Lactobacillus population [231]

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When IRE1 dissociates from GRP78, it undergoes oligomerization and auto-trans-phosphorylation to become IRE1