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In macrophages, elevated levels of nitric oxide synthase lead to increased production of both superoxide ions and NO

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A combination of ALA (50 M) and palmitoyl-ethanolamide (5 M) could reduce OxS (overproduction of ROS and NO) and modulate the major inflammatory cytokines (IL-, IL-6,TNF, and IL-10) involved in COVID-19 infection 534

Some of the possible factors that are abundant in CS are polyaromatic hydrocarbons (PAHs) that are inducers of cytochrome P450s and are well known sources of reactive oxygen species [28]