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According to a review in the Journal of Clinical Medicine, Vitamin A deficiency is associated with impaired mucosal immunity, reduced natural killer cell activity, and a weakened antibody response

(73) believed that the important mechanism for NOR to exert anti-RA characteristics might be to prevent the release of IL-6 from FLSs, and its mechanism might be related to the inhibition of PKC/MAPKs/p65/cAMP response element-binding protein (CREB) pathway

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If not closely managed, this can lead to side effects such as joint pain, fluid retention, insulin resistance, and other concerns