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Compared with earlier peptide therapeutics, tirzepatide demonstrates remarkable resistance to: Enzymatic cleavage Hydrolysis Chemical instability This is one reason it performs exceptionally well during long-term pharmaceutical stability studies

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For identification of dilated intercristae space, mitochondria were counted in 25 cells per condition

In toxicology studies, very high doses caused exaggerated pharmacological effects (such as marked weight loss and decreased nutritional intake in animals), but no organ toxicity or unexpected pathology