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Tumor heterogeneity adds complexity, as cancer cells vary in their susceptibility to ferroptosis (Liang et al., 2019) and cuproptosis, allowing some cells to evade death or develop resistance by enhancing antioxidant defenses or modulating metal metabolism

Hormonal Stability Many weight loss approaches disrupt multiple hormonal axes, creating cascading effects on appetite, stress response, thyroid function, and reproductive hormones

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is supported by the Wellcome Trust Leicestershire Healthcare Inequalities Improvement Doctoral Training Programme (223512/Z/21/Z)