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AMSCs treatment promotes mitochondrial function in APAP-challenged mice via the DDIT4/PGC-1 pathway To further determine the roles of AMSCs in promoting mitochondrial biogenesis and mitophagy through DDIT/PGC-1 in vivo, we detected the expression of PGC-1 in the livers of APAP-injured Ddit4 fl/fl and Ddit4 Hep mice after AMSCs treatment

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The study included application of transdermal patch having a size of 4 x 4 cm 2