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It functions as a metabolic modulator by inhibiting the NNMT enzyme, rather than acting as a signaling peptide

There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

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TB-500 is a peptide fragment of Thymosin Beta-4, a naturally occurring protein that encourages cell migration, new blood vessel formation, and tissue remodeling