It suppresses TNF- and IL-1 secretion from activated macrophages and stromal cells, downregulates matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF), thereby reducing extracellular matrix degradation, cell invasion, and pathological angiogenesis, and significantly decreases adhesion formation between ectopic lesions and adjacent peritoneal surfaces
AngII is clearly implicated in vascular remodeling because it greatly influences proliferation of and matrix deposition by VSMCs
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McInerney, J
