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Furthermore, in the li-pilocarpine induced chronic spontaneous epilepsy rat model, Tanshinone IIA reduced seizure severities and frequencies in a dose-dependent manner (10, 20, 30 mg/kg) and provided some protection for cognitive function [71]

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It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal

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A., et al., Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors, Science 344, no

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