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Diabetes Care 25 , 20482052 (2002)

Reconstitution with an appropriate sterile diluent (bacteriostatic water or sterile water for injection) is required before use

Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency

Singh S , Bedoy A, Nath D, Chang KH, Ostermann LB, Veletic I, Pacheco CD, Mak PY, Ayoub E, Muftuoglu M, Basyal M, Kim T, Hinkel RD, Garland KM, Angel M, Luther S, Rohde CB, Andreeff M