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First isolated in 1973 by Loren Pickart from human albumin fractions, this naturally occurring peptide found in blood plasma has since become one of the most investigated copper peptides in preclinical research, with findings that suggest broad implications for skin remodeling, inflammation reduction, and even central nervous system function

PMID 16551208

DON treatment activates AMPK in cancer cells by increasing the AMP/ATP ratio and decreasing the expression of c-Myc proteins, thereby inhibiting glycolytic metabolism and suppressing cancer cell growth in vitro 145