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cAMP/PKA Steroidogenic Signalling In primary mouse Leydig cell cultures, hCG was found to be approximately 10-fold more potent than LH in cAMP recruitment, and slightly but significantly more potent in cAMP-dependent Erk1/2 phosphorylation though no significant differences were observed at the level of downstream steroidogenic events including Creb phosphorylation, Stard1 gene expression, and testosterone synthesis

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Pretreatment with schisantherin A provided neuroprotection against induced cytotoxicity, regulated the intracellular accumulation of reactive oxygen species and inhibited NO overproduction by reducing the overexpression of inducible nitric oxide synthase in cells [206]