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Studies link DAG to pathological conditions, including tumor progression and cardiovascular disease, highlighting the critical roles of GPER-regulated IP3 and DAG in physiology and pathology

If taken late at night, a minority of users feel it could disrupt sleep or make it harder to wind down (this isnt universally reported, but caution is advised)

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Some abnormal plasma elevations of hemostatic parameters, including factor VIII (Freyburger et al, 1997), von Willebrand factor (van den Berg et al, 1995), fibrinogen (von Eckardstein et al, 1994), thrombomodulin (van den Berg et al, 1995), thrombin/antithrombin III complex and activated protein C (Cattaneo, 1999