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doi: 10.1161/JAHA.119.014044 224 PrakashRWaseemASiddiquiAJNaimeMKhanMARobertsonAAet al

197 reported increased total cysteine availability in the serum of women with ovarian tumours, regardless of whether the tumours were benign or malignant

Biochemically, ferroptosis is indicated by the inhibition of cystine/glutamate antiporter (System Xc ), the depletion of glutathione (GSH), decreased activity of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LOOH), and a decline in mitochondrial membrane potential (Mao et al., 2021

Understanding these risks is essential for safe supplementation: Gastrointestinal Distress : High doses may cause nausea, diarrhea, or abdominal cramps