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Women who are smokers are more likely to have low estrogen levels than women who are not smokers, which can lead to mood swings, fatigue, and vaginal dryness.[1] Research shows that among postmenopausal women, the number of cigarettes consumed daily was associated with increased levels of testosterone, free testosterone, 17-hydroxprogesterone, androstenedione, sex hormone-binding globulin, and estradiol.[4] Another study suggests that for premenopausal women, smoking, especially at moderate to heavy levels, may influence hormonal levels in women, potentially affecting menstrual cycle length and the levels of key hormones like estrogen and progesterone.[5] In summary, smoking can cause: Low estrogen levels Increased testosterone, free testosterone, 17-hydroxprogesterone, androstenedione, sex hormone-binding globulin, and estradiol How might these hormones affect a womans health