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Apart from the iron serving as co-factors and the iron stored in ferritin, the remaining divalent iron in the cytoplasm (a concentration of approximately 0.55 m) is called the free iron pool ( 2+ from generating ROS by the Fenton reaction to damage cells ( The uptake and storage of cellular iron mainly depend on the regulatory effects of the cytoplasmic protein iron regulatory protein (IRP)1 and IRP2 (Sty et al., 2011)