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Previous research has shown that GPx1 is an effective antioxidant enzyme that cannot be replaced by any other selenoprotein to protect against generalized oxidative stress [74,75,76]

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Brivio P., Gallo M.T., Gruca P., Lason M., Litwa E., Fumagalli F., Papp M., Calabrese F

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However, under non-stress conditions, these substitutions occurred in only 1.5% of cases and were largely neutral missense mutations, suggesting that does not typically result in dysfunctional protein aggregates in the absence of cellular stress