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Moreover, due to tumor heterogeneity, a biopsy from a single site may not represent the entire tumor's biological characteristics, potentially leading to misinterpretation of treatment responses, especially when tumor cells metastasize or develop drug resistance

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Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J (2022) Is melatonin the next vitamin D?: a review of emerging science, clinical uses, safety, and dietary supplements