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Advances in Gerontology, 1 , 240-243

Dynamic control by PcG and TrxG group Members of the PcG complex catalyze trimethylation of lysine 27 of histone 3 (H3K27me3), which leads to transcriptional repression through local heterochromatin formation (for review, see Cedar and Bergman (2009)) and/or inhibition of transcriptional elongation through stalling of RNA polymerase II (Stock et al., 2007)

Figures 1B , 3 ) is not fully ameliorated by conventional subcutaneous insulin administration, most likely because subcutaneous administration of insulin cannot fully compensate for the normal portal delivery of insulin to the liver