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32, 44 We further extend these findings by examining a larger sample of carefully selected tissues for multiple markers of oxidative protein/DNA damage (3-NT, 8-oxo-dG), as well as functional biomarkers of inflammation (3-CT) and mitochondrial superoxide production (aconitase activity)

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Immunogenicity The observed incidence of anti-drug antibodies is highly dependent on the sensitivity and specificity of the assay