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The low EAS effectiveness in vitiligo patients is related to its disabling caused by the chronic OS (Schallreuter et al., 1991a

Common causes include: Pernicious anemia, an autoimmune disorder hindering Vitamin B12 absorption Gastrointestinal surgeries, like gastrectomy, impact Vitamin B12 uptake Long-term use of certain medications, such as metformin or proton pump inhibitors Diets lacking in Vitamin B12, often seen in vegans and vegetarians For those without a deficiency, Vitamin B12 injections are not typically recommended, as their body can naturally regulate and excrete excess amounts of the vitamin

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Isolation and characterization of a novel peptide, osteoblast activating peptide (OBAP), associated with osteoblast differentiation and bone formation