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Furthermore, several terms upregulated in old indicate active metabolic detoxification processes (for example, alcohol metabolic process and cellular aldehyde metabolic process), as well as oxidative stress defense (for example, glutathione metabolic process) and remodeling of the extracellular matrix (for example, uronic acid metabolic process, extracellular matrix organization and biological adhesion)

In the airway, activated immune cells utilize antigen presentation to secrete cytokines such as interleukin (IL) 4, IL5, IL9, and IL13, which promote eosinophilic inflammation and induce IgE production [25]

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