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Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but the relevant phosphorylation sites are difficult to identify in cultured cells and to validate in isolated tissues

In summary, niacin is essential to the biochemistry of the nervous system, contributing to energy metabolism, neurotransmitter synthesis, such as serotonin and dopamine, antioxidant activities, and DNA repair (56)

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