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The review confirmed that glutathione peroxidases detoxify peroxides by a reaction coupled to GSH oxidation to GSSG with GSSG converted back to GSH by glutathione reductase and NADPH

In Perseus [29], the table with protein LFQ intensities was as well filtered for contaminants, after which the matrix was further filtered to contain at least three valid values in at least one of the groups

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This collective evidence firmly positions palmatine as a multi-target agent with integrated effects against insulin resistance, dysregulated lipid metabolism, and inflammation