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In ALL-derived cell lines and bone marrow mononuclear cells from ALL patients, 7 Wnt antagonists (sFRP1, sFRP2, sFRP4, sFRP5, WIF1, DKK3, and HDPR1) showed abnormal promoter methylation

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What a degraded product looks like: Discoloration (yellowish or cloudy solution that was previously clear), visible particulate matter, or unexpected viscosity change all suggest degradation or contamination