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256,257 The SASP secreted by senescent cells can also influence adjacent cells, including promoting tumor cell migration and metastasis, as well as facilitating angiogenesis and lymphangiogenesis by recruiting specific macrophages
This mechanism involves: Sequestration of monomeric actin (G-actin) to prevent premature polymerization Promotion of actin polymerization into functional microfilaments (F-actin) when needed Enhanced cellular migration through cytoskeletal reorganization Facilitation of cell shape changes necessary for wound healing Research indicates TB-500 may work with the Arp2/3 protein complex to orchestrate actin polymerization, though this mechanism requires further clarification[4]
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