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The treatment increased skin density and thickness, reduced fine lines and the depth of wrinkles, reduced photodamage and hyperpigmentation, improved skin clarity, and increased keratinocyte proliferation

doi: 10.1073/pnas.1607571113 408 YamanoESugimotoMHirayamaAKumeSYamatoMJinGet al

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With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy