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A relationship between long-term metformin use and vitamin B12 deficiency has been long discussed, and many readers will have come across this in clinical practice

Repeated freeze-thaw cycles should be avoided, as they can degrade the peptide and reduce potency

Preclinical and limited human studies indicate DSIP may modulate the hypothalamicpituitaryadrenal (HPA) axis and support healthy cortisol rhythms, making it of interest in stress-related sleep disruption