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It is vital to reestablish blood flow, but this act also contributes to neuronal injury by activating an immunological response and leading to endotoxicity, neuroinflammation, and oxidative and nitrosative stress, thereby worsening the outcome of ischemia (Chamorro et al., 2016

Other experimental agents use nasal spray for mucosal uptake

Relative contraindications may include significant cancer risk factors, bleeding disorders, and concurrent use of anticoagulant medications

Additional studies in dermal and corneal wound models have demonstrated TB-500s ability to upregulate VEGF, promoting angiogenesis and increasing nutrient delivery to damaged tissuesboth essential steps for robust tissue regeneration[5]