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For instance, in clinical settings, glutathione is sometimes used to help protect the kidneys of patients undergoing certain intensive medical treatments that are known to be hard on the renal system

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[21] [22] Studies of progeroid (premature aging) syndromes, which mimic the clinical and molecular characteristics of aging, have provided some insight into the mechanism of action of NAD+ replenishment

Additionally, data on rare germline pathogenic variants, for example, in DNA damage repair or tumour-suppressor genes, are emerging from somatic mutation profiling studies (WES and/or WGS analyses) that use matched non-malignant tissues for comparison 150