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The principal outcomes associated with heightened production of nitric oxide (NO) include the formation of the neurotoxic substance peroxynitrite, as well as an increase in nitrosylation, which pertains to nitroso-binding to proteins [7]

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Lack of Creatine production results in prolonged lack of energy, with prolonged over-usage or underproduction eventually leading to the subject being chronically fatigued (CFS) Reduced production of Creatine has been associated with many conditions including dementia, Parkinson's disease, Autism, Chronic Fatigue Syndrome