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Specifically, lipid peroxidation products such as 4-HNE can act as endogenous danger signals, activating the NF-B pathway and the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, subsequently triggering the release of potent inflammatory cytokines like IL-1 and tumor necrosis factor-alpha (TNF-)

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Statistical significance was assessed in GraphPad Prism and tested by one- or two-way ANOVA for repeated measurements followed by Tukeys multiple comparison test, or unpaired one-way ANOVA followed by Tukeys multiple comparison test

However, the polyphenols therapeutic potential is becoming more and more evident, enticing the worldwide researchers with a landscape of therapeutic possibilities to uncover the precise and effective biological role of this molecules in counteract oxidative stress, enabling their implementation in preventive healthcare practices, according to the evidence-based dentistry [168]