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Additionally, cytosolic LPS is directly sensed by inflammatory caspases (e.g., Caspase-4), triggering non-canonical inflammasome responses and pyroptosis, which further amplifies systemic inflammation 144

Syringe size is not the same as needle gauge or needle length

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial