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192 Additionally, molecular biophysics research explores the role of integrins and other mechanosensitive proteins in mediating the cellular response to mechanical stress

Population-based studies consistently demonstrate that individuals with CVDs face a significantly elevated risk of developing cognitive impairment, including dementia [1, 2]

Demonstrating perfect causality is impossible to fulfill (Vega, 2021), but providing a framework in which the question of AD etiology including MAD and where other theories can be incorporated is proposed in Figure 3