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Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody

Glutathione - Synthesis SFRBM Education Program Dickinson et al.15 Glutathione breakdown 2 GGT is an ectoenzyme (it exists functionally on the outside of cells)

Abbreviations MAFLD: Metabolic dysfunction-associated fatty liver disease MAFL: Metabolic Associated Fatty Liver MASH: Metabolic Associated Steatohepatitis MASLD: Metabolic Dysfunction-Associated Steatotic Liver Disease NAFLD: Non-Alcoholic Fatty Liver Disease NASH: Non-Alcoholic Steatohepatititis MetS: Metabolic syndrome AMPK: 5 adenosine monophosphate-activated protein kinase T2DM: Type 2 diabetes mellitus SESN: Sestrin miRNA: MicroRNAs ADAR: Adenosine deaminases acting on RNA FGF21: Fibroblast growth factor 21 FABP1: Fatty acid-binding protein 1 IL-6: Interleukin-6 PLIN: Perilipin LAMP1: Lysosomal associated membrane protein 1 CaMKK: Calcium/Calmodulin-Dependent Protein Kinase Kinase CREB: cAMP Response Element-Binding Protein ACC: Acetyl-CoA carboxylase CPT1: Carnitine Palmitoyltransferase 1 SREBP1c: Sterol Regulatory Element-Binding Protein 1c Scd1: Stearoyl-CoA desaturase 1 VEGFB: Vascular Endothelial Growth Factor B mTORC1: Mechanistic target of rapamycin complex 1 mTORC2: Mechanistic target of rapamycin complex 2 Akt: Protein kinase B Nrf2: Nuclear factor erythroid 2-related factor 2 Keap1: Kelch-like ECH-associated protein 1 AREs: Antioxidant response elements LC3: Microtubule-associated protein 1 light chain 3 SQSTM1: Sequestosome 1 ATP6V0D1: Lysosomal H-transporting ATPase CTSD: Cathepsin D PPAR: Peroxisome proliferator-activated receptor Mfn-2: Mitofusin-2 GPX4: Glutathione peroxidase 4 GSH: Glutathione ROS: Reactive oxygen species PUFAs: Polyunsaturated fatty acids ACSL4: Acyl-CoA synthetase long-chain family member 4 ALOX15: Arachidonate 15-lipoxygenase Nrg4: Neuregulin 4 EGF: Epidermal growth factor ErbB4: Epidermal Growth Factor Receptor 4 cGAS: Cyclic guanosine monophosphate-adenosine monophosphate synthase STING: Stimulator of interferon genes STAT5a: Signal transducer and activator of transcription 5a LXR: Liver X receptor FASN: Fatty acid synthase TG: Triglycerides IR: Insulin resistance TNF-: Tumor necrosis factor- HCC: Hepatocellular carcinoma PDM: Peridroplet mitochondria WB: Western blot IPA: Ingenuity Pathway Analysis FFA: Free fatty acid HFD: High fatty diet PI3K: Phosphatidylinositol 3-kinase RXR: Retinoid X receptor SCAP: SREBP cleavage-activating protein SRE: Sterol regulatory element NPC: Nuclear pore complex RISC: RNA-induced silencing complex IRF3: Interferon regulatory factor 3 NF-B: Nuclear factor kappa-B c/EBP: CCAAT-enhancer-binding protein HIF-1: Hypoxia-Inducible Factor 1 FOXO: Forkhead Box O ALT: Alanine Aminotransferase AST: Aspartate Aminotransferase LBP: Leucine-binding Pocket MCD: MethionineCholine-deficient Lip-1: Liproxstatin-1 PPRE: Peroxisome Proliferator Response Element STING: Stimulator of Interferon Genes TBK1: TANK-Binding Kinase 1 TAG: Triacylglycerols SE: Sterol Esters GADD: Growth Arrest and DNA Damage-Inducible Gene ULK1: Unc-51-like Kinase 1 NQO1: NAD(P)H Quinone Dehydrogenase 1 GST: Glutathione S-Transferase References Abdelhameed F, Kite C, Lagojda L, Dallaway A, Chatha KK, Chaggar SS, et al

If this was true, then redheads do not need sun exposure to be at heightened risk of melanoma AND anything that stimulates red pigment (tanning) is especially damaging