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Thus, dietary supplement B 12 supplementation at 500 to 1000 g per day allows pernicious anemia and certain other defects in B 12 absorption to be treated with daily oral megadoses of B 12 without any correction of the underlying absorption defects

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Starting Too High The most frequent and dangerous mistake is starting immediately at a standard or advanced dose

Preclinical work suggested the weight loss exceeded what reduced eating alone would predict, which points to the body genuinely burning more rather than simply eating less