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Since the development of PVI as the first truly effective catheter-based ablation procedure for AF, many additional LA ablation targets have been introduced to improve on the success of PVI (some examples are shown in Figure 2), but systematic evidence demonstrating a significant improvement in success-rates over PVI alone is lacking and PVI is still the only universally-accepted ablation procedure for AF

Squamous cell carcinomas are much more commonly endobronchial lesions protruding into and obstructing large central bronchus, while adenocarcinomas are much more commonly peripheral [37]

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