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Umweltwiss Schadst Forsch 17(1):5053 Sandermann H (1994) Higher plant metabolism of xenobiotics: the green liver concept

This is strongly recommended that such medications are not used in the long term to avoid such a decrease in CYP signals and spermatocyte counts in the testes

No IGF-1 elevation: HGH increases insulin-like growth factor 1 (IGF-1), which promotes growth of all tissues - including potentially problematic growth

Coadministration of pemigatinib with a strong or moderate CYP3A inhibitor such as itraconazole should also be avoided if possible as it can lead to clinically significant increases in pemigatinib exposure (Incyte Corporation, 2022)