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HMGB1 acts by binding to various receptors, including RAGE and TLR2, TLR4, and TLR9 [254,255]

Immune cells from aged versus nonaged adult killifish display different functional responses to LPS stimulation and have increased markers of senescence To test whether the molecular and cellular changes we observed in the killifish kidney marrow during aging are associated with an impaired immune cells response in vitro, we adopted an assay that measures immune cell activation in the presence of LPS, a potent immune stimulator 54 (Fig

Lactate metabolism in human lung tumors

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