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For reference, the four prostaglandins are prostaglandin (PG) E2 (PGE2), prostacyclin (PGI2), prostaglandin D2 (PGD2) and prostaglandin F2alpha (PGF2alpha), and the two thromboxanes are thromboxane A2 (TXA2) and thromboxane B2 (TXB2)

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The component-resolved HPLC panel, the multi-target LC-MS run, the ICP copper measurement, and the LAL endotoxin assay all have to clear against pre-locked criteria before the lot is signed off, with a partial pass on any single assay triggering a hold rather than conditional release

But critics fear the FDAs stamp of approval will simply legitimize the use of unproven substances whose dangers may only become apparent in coming years