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Sig Transduct Target Ther 9 , 30 (2024)
Four dogs with spontaneous cancer were used to test the anti-tumor effects of nitrosylcobalamin (NO-Cbl), a vitamin B12-based carrier of nitric oxide (NO) that induces apoptosis
(2) the phosphatidylinositol 3-kinase complex 1, composed of vacuolar protein sorting proteins such as Beclin 1, PI3KR4, and PI3KC3 in mammals, responsible for the nucleation phase by directing proteins to the PAS through the generation of phosphatidylinositol 3-phosphate (PIP3) (Kihara et al., 2001
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