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Free Radic Biol Med 152:375385 Zong Y, Li H, Liao P, Chen L, Pan Y, Zheng Y et al (2024) Mitochondrial dysfunction: mechanisms and advances in therapy

Retatrutide targets three different receptors: GLP-1 (helps regulate appetite and blood sugar) GIP (supports insulin response) Glucagon (affects energy use and fat metabolism) By targeting all three, the medication delays how fast your stomach digests food, lowers your appetite, and ultimately reduces how much food you eat

Ipamorelin acts as a selective ghrelin mimetic, triggering acute GH secretion without spiking cortisol or prolactin

If variances were statistically different, data was then analyzed using a Kruskal-Wallis test followed by a Dunns Multiple Comparison post-test