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Rather than supplying GH directly, they trigger GH release through the bodys own mechanisms, maintaining the pulsatile secretion pattern and feedback inhibition that characterize normal physiology

Luther, D

Pharmacol Ther 234:108117 Apostolova N, Gomez-Sucerquia LJ, Moran A, Alvarez A, Blas-Garcia A, Esplugues J (2010) Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells

Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3